Unander A M, Olding L B
Am J Reprod Immunol (1980). 1982 Oct;2(5):254-9. doi: 10.1111/j.1600-0897.1982.tb00178.x.
This investigation involves 3 women with habitual abortion and 2 women with multiple normal pregnancies. Extensive clinical investigations failed to reveal any cause for the abortions. All husbands were ABO-compatible with their respective wives. The women shared three, two, and zero of five identified HLA-A antigens with their respective husbands. None of the women had any cytotoxic antibody. Lymphocytes from all three women reacted normally in one-way mixed lymphocyte cultures to their husbands' alloantigens. Cell-mediated lympholysis was similar in couples with habitual abortion and in those with repeated normal pregnancies. The women's lymphocytes' proliferation was significantly suppressed by lymphocytes from their husbands and by those from most male controls in two-way mixed lymphocyte culture and double chamber experiments. Two women with 6 and 5 live-born children, respectively, served as controls. Their lymphocytes were not suppressed by lymphocytes from their respective husbands or by those from most male controls in two-way mixed lymphocyte cultures. Their reactions in one-way mixed lymphocyte cultures and in cell-mediated lympholysis, however, did not differ from those of the women with habitual abortion.
本研究涉及3名习惯性流产女性和2名多次正常妊娠女性。广泛的临床调查未能揭示流产的任何原因。所有丈夫与各自妻子的ABO血型相容。这些女性与各自丈夫分别共有5种已鉴定的HLA - A抗原中的3种、2种和0种。这些女性均无细胞毒性抗体。在单向混合淋巴细胞培养中，所有3名女性的淋巴细胞对其丈夫的同种异体抗原反应正常。习惯性流产夫妇和反复正常妊娠夫妇的细胞介导淋巴细胞溶解情况相似。在双向混合淋巴细胞培养和双室实验中，这些女性的淋巴细胞增殖受到其丈夫的淋巴细胞以及大多数男性对照者的淋巴细胞的显著抑制。分别有6个和5个存活子女的2名女性作为对照。在双向混合淋巴细胞培养中，她们的淋巴细胞未受到各自丈夫的淋巴细胞或大多数男性对照者的淋巴细胞的抑制。然而，她们在单向混合淋巴细胞培养和细胞介导淋巴细胞溶解中的反应与习惯性流产女性的反应并无差异。
