每天给儿童单剂量缓释茶碱进行治疗。
Treatment of children with a single dose a day of sustained release theophylline.
作者信息
Pedersen S
出版信息
Br J Clin Pharmacol. 1982 Aug;14(2):290-1. doi: 10.1111/j.1365-2125.1982.tb01978.x.
Abstract
Six children were given a single dose of theophylline (Nuelin Retard) (median dose 13.2 mg/kg) after a large breakfast, rich in carbohydrates, for 4 days. On 5 serum levels of theophylline were measured over the following 24 h. Absorption of theophylline was slow and acceptable peak to trough differences were demonstrated. However subtherapeutic serum levels of theophylline were recorded in all children at some time during the dose interval.
摘要
六名儿童在连续四天享用富含碳水化合物的丰盛早餐后，接受了单次剂量的茶碱（Nuelin缓释剂）（中位剂量13.2毫克/千克）。在第5天，于接下来的24小时内测定了茶碱的血清水平。茶碱的吸收缓慢，且呈现出可接受的峰谷差异。然而，在给药间隔期间的某些时间，所有儿童的血清茶碱水平均记录为低于治疗水平。
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