Haahtela T, Suoniemi I, Jaakonmäki I, Björkstén F
Allergy. 1982 Nov;37(8):597-602. doi: 10.1111/j.1398-9995.1982.tb02346.x.
We studied serum IgE concentration by the PRIST method in 157 adolescents (71 boys) aged 15-17 years. This group was randomly drawn from a larger unselected population of 708 young people. The geometric mean IgE for the 157 subjects was 37.6 U/ml. After careful exclusion 77 subjects without any signs or symptoms of atopy were found. The mean IgE for them was 16.8 U/ml and the upper reference limit, calculated as mean +/- 2 SD of the logarithmic value, was 160 U/ml. Nineteen per cent of the population had an IgE concentration higher than 160 U/ml and 30% had a value below 20 U/ml. Positive skin test reactions were strongly associated with increased IgE values. Atopic eczema and allergic rhinitis also raised the IgE level, but the effect of bronchial wheezing was insignificant. We conclude that IgE concentrations above 160 U/ml during adolescence suggest atopy and correlate with positive skin test reactivity and/or clinical symptoms. An IgE value below 20 U/ml almost certainly excludes the possibility of positive skin reactions and somewhat less certainly the possibility that symptoms are due to atopy.
我们采用PRIST法对157名年龄在15至17岁的青少年（71名男孩）的血清IgE浓度进行了研究。该组是从708名年轻人的未经过筛选的较大群体中随机抽取的。157名受试者的IgE几何平均值为37.6 U/ml。经过仔细排除，发现77名无任何特应性体征或症状的受试者。他们的平均IgE为16.8 U/ml，以对数值得出的上限参考值，即均值±2标准差，为160 U/ml。19%的人群IgE浓度高于160 U/ml，30%的人群IgE值低于20 U/ml。阳性皮肤试验反应与IgE值升高密切相关。特应性皮炎和过敏性鼻炎也会使IgE水平升高，但支气管哮喘的影响不显著。我们得出结论，青少年时期IgE浓度高于160 U/ml提示特应性，并与阳性皮肤试验反应性和/或临床症状相关。IgE值低于20 U/ml几乎可以肯定排除阳性皮肤反应的可能性，对于症状由特应性引起的可能性排除把握稍小一些。
