Horak F
Arch Otorhinolaryngol. 1985;242(3):239-45. doi: 10.1007/BF00453546.
In a prospective study of allergic rhinitis in latent-sensitized young patients, 114 children were observed over a period of 4 years. At the beginning of the study, all patients were found to be sensitive to inhalant allergens but without any signs of clinical manifestations. Each patient's rhinologic and allergic status was checked in yearly follow-up examinations to determine the incidence of allergic rhinitis becoming clinically apparent and to define special risk characteristics. During the period of observation, 53% of the children developed manifest allergic rhinitis, while an additional 5% developed clinical symptoms of allergic bronchial asthma. Patients who showed monovalent sensitivity formed a special risk group, especially if they were sensitized to pollen. A continuously increasing serum IgE titer, increased concentrations of specific IgE, and skin tests were used as prognostic criteria to predict imminent clinical manifestations.
在一项针对潜伏致敏年轻患者过敏性鼻炎的前瞻性研究中，对114名儿童进行了为期4年的观察。研究开始时，所有患者均被发现对吸入性过敏原敏感，但无任何临床表现迹象。在每年的随访检查中，对每位患者的鼻科和过敏状况进行检查，以确定过敏性鼻炎出现临床症状的发生率，并确定特殊风险特征。在观察期间，53%的儿童出现明显的过敏性鼻炎，另有5%出现过敏性支气管哮喘的临床症状。表现为单价敏感性的患者形成了一个特殊风险组，尤其是对花粉致敏的患者。血清IgE滴度持续升高、特异性IgE浓度升高以及皮肤试验被用作预测即将出现临床表现的预后标准。
