Stewart G J, Pollard J D, McLeod J G, Wolnizer C M
Ann Neurol. 1978 Sep;4(3):285-9. doi: 10.1002/ana.410040317.
Forty-four patients with inflammatory demyelinating polyneuritis (22 with Landry-Guillain-Barré syndrome, 6 with subacute polyneuritis, and 16 with chronic relapsing polyneuritis) were typed for genetic markers in and around the HLA region of chromosome 6. Patients with chronic relapsing polyneuritis showed a definite association with HLA-AW30 and AW31 and probable associations with HLA-B8, HLA-DW3, and glyoxalase I. No significant associations were demonstrated with the Landry-Guillain-Barré syndrome although an increase in glyoxalase I was significant if combined with the results of typing in chronic relapsing polyneuritis. The total patient group showed significant increases in HLA-AW30, HLA-AW31, and HLA-DW3. The results support the view that HLA-linked genetic factors influence susceptibility to chronic relapsing polyneuritis and may contribute to the differences in clinical patterns observed in inflammatory demyelination of the peripheral nervous system.
对44例炎性脱髓鞘性多发性神经炎患者（22例患有Landry - Guillain - Barré综合征，6例患有亚急性多发性神经炎，16例患有慢性复发性多发性神经炎）进行了6号染色体HLA区域及其周围遗传标记的分型。慢性复发性多发性神经炎患者与HLA - AW30和AW31有明确关联，与HLA - B8、HLA - DW3和乙二醛酶I可能有关联。Landry - Guillain - Barré综合征未显示出显著关联，不过若将乙二醛酶I的检测结果与慢性复发性多发性神经炎的分型结果相结合，则其升高具有显著性。患者总体组中HLA - AW30、HLA - AW31和HLA - DW3显著增加。这些结果支持这样一种观点，即与HLA相关的遗传因素影响对慢性复发性多发性神经炎的易感性，并且可能导致在周围神经系统炎性脱髓鞘中观察到的临床模式差异。
