Grunnet M
Arch Pathol Lab Med. 1982 Feb;106(2):81-2.
In 1979, the appearance of the periventricular leukomalacia complex (PLC) was reported in a relatively high percent of infants coming to autopsy from our neonatal intensive care unit. Because infants with PLC had had longer periods of high P02 than did those without PLC, it was concluded that PLC was related to hyperoxia. However, in a second study it was found that the periods of hyperoxia corresponded to periods of hypotension. Therefore, the complete autopsies of 16 randomly selected newborn subjects with PLC and 21 without PLC were reviewed with particular reference to the incidence of bronchopulmonary dysplasia (BPD), a lesion thought to be due to high levels of oxygen in inspired air. The incidence of BPD in newborn subjects with PLC was essentially the same as in those without PLC (7/16 or 44% vs 9/21 or 43%). Moreover, three newborn subjects with PLC and none without PLC showed renal tubular necrosis, a lesion usually associated with severe hypotension. This suggests that PLC is related to hypotension rather than to hyperoxia.
1979年，据报告，在我们新生儿重症监护病房接受尸检的婴儿中，相当高比例的婴儿出现了脑室周围白质软化症（PLC）。由于患有PLC的婴儿比未患PLC的婴儿有更长时间处于高氧状态，因此得出结论，PLC与高氧有关。然而，在第二项研究中发现，高氧期与低血压期相对应。因此，对16名随机选择的患有PLC的新生儿和21名未患PLC的新生儿进行了完整的尸检，特别关注支气管肺发育不良（BPD）的发生率，BPD被认为是由吸入空气中的高氧水平引起的病变。患有PLC的新生儿中BPD的发生率与未患PLC的新生儿基本相同（7/16或44%对9/21或43%）。此外，3名患有PLC的新生儿出现肾小管坏死，而未患PLC的新生儿无一出现，肾小管坏死是一种通常与严重低血压相关的病变。这表明PLC与低血压有关，而非与高氧有关。
