[Sinus histiocytosis of the regional lymph nodes as an indicator of antitumor resistance in breast cancer].

Sinusal histiocytosis (SH) of regional lymph nodes was examined in 100 patients with mammary gland carcinoma in relation to the clinico-morphological characteristics of the tumor and values of the immunity system of the patients. Among patients with SH (43.4%) 84.8% had tumors of the I and II degree of malignancy; moderately and highly differentiated carcinoma (57.4% and 36.0%, respectively), non-metastasizing tumors (63.4%) with marked stromal reaction (51.5%), moderate mitotic activity of tumor cells (5.5 +/- 0.73%) prevailed in the I stage of the process (42.4%). In 64.3% patients of this group the content of T- and B-lymphocytes in the blood was within normal range, in 56.6% the reaction of the delayed type hypersensitivity was positive. Weakening and lack of histiocytic reaction was accompanied by progression of the tumor, increase of cytomorphological and clinical criteria of malignancy, inhibition of the functional activity of lymph nodes, decreased immunological responsiveness. A possible role of SH in the anti-tumor defence and the prognostic importance of this morphological test are noted.