Loboda V I, Grinevich Iu A
Arkh Patol. 1982;44(10):45-9.
Sinusal histiocytosis (SH) of regional lymph nodes was examined in 100 patients with mammary gland carcinoma in relation to the clinico-morphological characteristics of the tumor and values of the immunity system of the patients. Among patients with SH (43.4%) 84.8% had tumors of the I and II degree of malignancy; moderately and highly differentiated carcinoma (57.4% and 36.0%, respectively), non-metastasizing tumors (63.4%) with marked stromal reaction (51.5%), moderate mitotic activity of tumor cells (5.5 +/- 0.73%) prevailed in the I stage of the process (42.4%). In 64.3% patients of this group the content of T- and B-lymphocytes in the blood was within normal range, in 56.6% the reaction of the delayed type hypersensitivity was positive. Weakening and lack of histiocytic reaction was accompanied by progression of the tumor, increase of cytomorphological and clinical criteria of malignancy, inhibition of the functional activity of lymph nodes, decreased immunological responsiveness. A possible role of SH in the anti-tumor defence and the prognostic importance of this morphological test are noted.
对100例乳腺癌患者区域淋巴结的窦组织细胞增生（SH）进行了检查，分析其与肿瘤的临床形态学特征及患者免疫系统指标的关系。在伴有SH的患者中（占43.4%），84.8%患有I级和II级恶性肿瘤；其中，中度和高分化癌分别占57.4%和36.0%，非转移性肿瘤占63.4%，伴有明显间质反应的占51.5%，肿瘤细胞有中度有丝分裂活性的占5.5±0.73%，这些情况在病程I期最为常见（占42.4%）。该组64.3%患者血液中T淋巴细胞和B淋巴细胞含量在正常范围内，56.6%患者迟发型超敏反应呈阳性。组织细胞反应减弱和缺乏伴随着肿瘤进展、恶性肿瘤细胞形态学和临床标准的增加、淋巴结功能活性的抑制以及免疫反应性降低。文中指出了SH在抗肿瘤防御中的可能作用以及该形态学检查的预后重要性。
