Cooke H J, Schmidtke J, Gosden J R
Chromosoma. 1982;87(5):491-502. doi: 10.1007/BF00333470.
The human Y chromosome carries 2000 copies of a tandemly repeated sequence, 2.47 kb long, which constitutes about 20% of the DNA of this chromosome. These sequences are localised on the tip of the long arm of the Y chromosome. Related sequences are present in DNA of females with a related but distinguishable restriction pattern. These autosomal sequences are distributed in tandem arrays on a number of autosomes. Related sequences are also present in gorilla and chimpanzee. In gorilla they resemble the human sequences in their restriction map but are not found on the Y chromosome whereas in chimpanzee the related sequences behave as a 'dispersed' repeat. Changes in the level of methylation of this sequence in different tissues of human males can be detected with the lowest levels found in sperm and placental DNA.
人类Y染色体携带2000个串联重复序列拷贝，长度为2.47 kb，约占该染色体DNA的20%。这些序列位于Y染色体长臂的末端。相关序列存在于具有相关但可区分的限制性图谱的女性DNA中。这些常染色体序列以串联阵列的形式分布在多个常染色体上。大猩猩和黑猩猩的DNA中也存在相关序列。在大猩猩中，它们在限制性图谱上类似于人类序列，但在Y染色体上未发现，而在黑猩猩中，相关序列表现为“分散”重复。可以检测到人类男性不同组织中该序列甲基化水平的变化，精子和胎盘DNA中的水平最低。
