Sedgwick A D, Edwards J C, Willoughby D A
Int J Tissue React. 1983;5(1):11-7.
D-penicillamine was found to have a pro-inflammatory effect when given to rats during the formation of carrageenan air pouch granulomas or simple air cavity linings. Unlike dexamethasone, D-penicillamine had no effect on the strength of the cavity lining in either system. D-penicillamine had no effect on the chemoattractant properties of the carrageenan-induced exudates or on the responsiveness of cells from such exudates to a chemoattractant. These results suggest that D-penicillamine has a short-term pro-inflammatory effect on non-immune responses to tissue injury, but the mechanism remains unclear.
在角叉菜胶气囊肿肉芽肿形成或单纯气腔衬里形成过程中给大鼠注射D-青霉胺时，发现其具有促炎作用。与地塞米松不同，D-青霉胺对这两种系统中气腔衬里的强度均无影响。D-青霉胺对角叉菜胶诱导的渗出物的趋化特性或此类渗出物中的细胞对趋化剂的反应性均无影响。这些结果表明，D-青霉胺对组织损伤的非免疫反应具有短期促炎作用，但其机制尚不清楚。
