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脊髓损伤儿童的高钙血症

Hypercalcemia in children with spinal cord injury.

作者信息

Tori J A, Hill L L

出版信息

Arch Phys Med Rehabil. 1978 Oct;59(10):443-6.

PMID:718406
Abstract

Eighty-seven children less than 16 years of age with recent spinal cord injury were studied during a 7-year period (1970--1976). Serum calcium concentration was determined at least once in each of 76 of these patients, and in 18 (23.6%) it was above 11 mg%. Fifteen of the 18 patients had quadriplegia and 3 had paraplegia. In 5 patients, the first symptoms of acute hypercalcemia simulated those of an acute abdomen. Two of the 5 patients underwent exploratory laparotomy, with negative findings. The incidence of urinary stones was 55% (10 of the 18), a difference from the control population of only 18%. Hypercalcemia in the acute phase was almost always accompanied by decreased renal function characterized by inability to concentrate the urine and low corrected creatinine clearance. The treatment with saline infusions and furosemide was usually effective.

摘要

在7年期间(1970 - 1976年),对87名16岁以下近期发生脊髓损伤的儿童进行了研究。其中76名患者至少测定了一次血清钙浓度,18名(23.6%)患者的血清钙浓度高于11mg%。这18名患者中15名患有四肢瘫痪,3名患有截瘫。5名患者急性高钙血症的首发症状类似急腹症。这5名患者中有2名接受了剖腹探查术,结果为阴性。尿路结石的发生率为55%(18名患者中有10名),与对照组人群的差异仅为18%。急性期高钙血症几乎总是伴有肾功能下降,表现为尿液浓缩功能障碍和校正肌酐清除率降低。静脉输注生理盐水和呋塞米治疗通常有效。

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