Nishi M, Takao S, Aiko T
Gan To Kagaku Ryoho. 1982 May;9(5):790-8.
The relationship between gastrointestinal cancers and genetic influence was investigated. The subjects examined were 1211 cancer cases and 781 non-cancer cases registered to the 1st Department of Surgery of Kagoshima University Hospital from 1972 to 1980. The results were as follows: 1. Malignant cases were found in 266/1211 (22.0%) in the families of cancer probandus. Incidence was significantly (P less than 0.01) higher than that [130/781 (16.6%)] in those of non-cancer probandus. 2. Malignant cases were found in 79/356 (22.2%) in the families of gastric cancer probandus and in 51/189 (27.0%) in those of colo-rectal cancer probandus. 3. The relationship between cancer probandus and malignant cases in the families was classified according to the vertical relationship (grandparents-parents-uncle and aunt-probandus-children) and the horizontal relationship (probandus-siblings-cousin). 4. Incidence in the vertical relationships (159/266: 59.8%) was higher than that in the horizontal relationships (107/266: 40.2%). Incidence of the vertical relationships of female cancer probandus (gastric cancer: 70.4%, esophageal cancer: 55.7%, clorectal cancer: 73.9%) was significantly (P less than 0.05) higher than that in those of male cancer probandus. 5. Incidence of blood B type in male gastric cancer group tended to be less when compared with the control group (P less than 0.05). 6. Incidence of smoking habits in esophageal cancer group (82.2%) and the lung cancer group (63.4%) was significantly (P less than 0.01) higher than that in the control group (46.0%). 7. Incidence of drinking habits in the male esophageal cancer group (84.2%) was significantly (P less than 0.01) higher than that in the control group (53.0%).
对胃肠道癌症与遗传影响之间的关系进行了调查。研究对象为1972年至1980年在鹿儿岛大学医院第一外科登记的1211例癌症病例和781例非癌症病例。结果如下：1. 在癌症先证者的家族中，266/1211例（22.0%）发现恶性病例。其发病率显著高于（P<0.01）非癌症先证者家族中的发病率[130/781例（16.6%）]。2. 在胃癌先证者的家族中，356例中有79例（22.2%）发现恶性病例，在结直肠癌先证者的家族中，189例中有51例（27.0%）发现恶性病例。3. 根据垂直关系（祖父母-父母-叔伯姑母-先证者-子女）和水平关系（先证者-兄弟姐妹-堂表亲）对先证者与家族中恶性病例之间的关系进行分类。4. 垂直关系中的发病率（159/266：59.8%）高于水平关系中的发病率（107/266：40.2%）。女性癌症先证者垂直关系的发病率（胃癌：70.4%，食管癌：55.7%，结直肠癌：73.9%）显著高于（P<0.05）男性癌症先证者。5. 男性胃癌组中B型血的发病率与对照组相比有降低趋势（P<0.05）。6. 食管癌组（82.2%）和肺癌组（63.4%）的吸烟习惯发病率显著高于（P<0.01）对照组（46.0%）。7. 男性食管癌组的饮酒习惯发病率（84.2%）显著高于（P<0.01）对照组（53.0%）。
