Tominaga K, Koyama Y, Sasagawa M, Hiroki M, Nagai M
Department of Cancer Detection, Tochigi Cancer Center.
Jpn J Cancer Res. 1991 Sep;82(9):974-9. doi: 10.1111/j.1349-7006.1991.tb01930.x.
A case-control study of stomach cancer and its genesis has been conducted in relation to alcohol consumption, cigarette smoking, and familial cancer history. Two hundred and ninety-four cancer cases, discovered by mass screening and histologically verified after endoscopic examination, have been compared with 588 randomly selected controls, who received the same early detection program and were verified as being free of the disease. No statistically significant association was observed between the development of stomach cancer and alcohol consumption or familial cancer history. However, the development of stomach cancer was found to have a positive correlation with smoking (relative risk for those who smoke less than 19 cigarettes/day, 3.56: 95% confidence interval, 2.39 to 5.31; relative risk for those who smoke more than 20 cigarettes/day, 2.58: 95% confidence interval, 1.60 to 4.17). The results of this study suggest that cigarette smoking appears to have a more harmful effect on the development of stomach cancer than either alcohol consumption or a familial history of cancer. The high relative risk of smoking revealed by this study implies that further research on the effects of smoking in the development of stomach cancer would be desirable.
针对饮酒、吸烟及家族癌症病史，开展了一项关于胃癌及其发病机制的病例对照研究。通过大规模筛查发现并经内镜检查后组织学确诊的294例癌症病例，与588例随机选择的对照进行了比较，这些对照接受了相同的早期检测项目，且经核实未患该病。未观察到胃癌发生与饮酒或家族癌症病史之间存在统计学显著关联。然而，发现胃癌发生与吸烟呈正相关（每天吸烟少于19支者的相对风险为3.56：95%置信区间为2.39至5.31；每天吸烟超过20支者的相对风险为2.58：95%置信区间为1.60至4.17）。本研究结果表明，吸烟对胃癌发生的危害似乎比饮酒或癌症家族史更大。本研究揭示的吸烟的高相对风险意味着，有必要进一步研究吸烟在胃癌发生中的作用。
