Wilkinson E J, Rico M J, Pierson K K
Int J Gynecol Pathol. 1982;1(1):29-39. doi: 10.1097/00004347-198201000-00005.
Thirty cases of microinvasive squamous cell carcinoma of the vulva were seen from 1972 to 1978 inclusive. They comprised 37.7% of 77 cases of squamous carcinoma of the vulva seen during this period of time. The results of analysis of multiple factors, including tumor depth and pattern of invasion, nuclear and histologic grade, volume, inflammatory response, presence of vascular invasion, and depth of invasion as compared to the depth of adjacent skin appendages and rete ridges are presented. Two patients were found to have inguinal lymph node metastasis: in one of these patients the tumor was deeper than the adjacent deepest skin appendages while in the second patient skin appendages were not adjacent to the tumor. These tumors measured 2.25 and 1.8 mm in depth, respectively. In both patients the tumor was of high nuclear grade and had a diffuse pattern of infiltration. No nodal metastases were found in patients whose tumors did not invade deeper than 1.5 mm or deeper than the adjacent deepest skin appendage. Tumors measuring 1.5 mm in depth had tumor volumes under 1,000 mm3. The only death from tumor that occurred in this series occurred in a woman who had a second primary tumor of the vulva following a local excision for her microinvasive carcinoma. The definition and measurements of microinvasive carcinoma of the vulva are discussed and an improved method of measurement is proposed.
1972年至1978年（含）共观察到30例外阴微浸润性鳞状细胞癌。它们占同期所见77例外阴鳞状细胞癌的37.7%。本文呈现了对多个因素的分析结果，这些因素包括肿瘤深度和浸润模式、核分级和组织学分级、体积、炎症反应、血管浸润情况，以及与相邻皮肤附属器和 rete 嵴深度相比的浸润深度。发现2例患者有腹股沟淋巴结转移：其中1例患者的肿瘤比相邻最深的皮肤附属器更深，而另一例患者的肿瘤与皮肤附属器不相邻。这些肿瘤的深度分别为2.25毫米和1.8毫米。两名患者的肿瘤均为高核分级且呈弥漫性浸润模式。肿瘤浸润深度不超过1.5毫米或不超过相邻最深皮肤附属器深度的患者未发现淋巴结转移。深度为1.5毫米的肿瘤体积小于1000立方毫米。该系列中唯一的肿瘤死亡病例发生在一名女性身上，她在对外阴微浸润癌进行局部切除后出现了外阴第二原发性肿瘤。本文讨论了外阴微浸润癌的定义和测量方法，并提出了一种改进的测量方法。
