Springer D L, Poston K A, Mahlum D D, Sikov M R
J Appl Toxicol. 1982 Oct;2(5):260-4. doi: 10.1002/jat.2550020509.
On days 12-16 of gestation pregnant rats were exposed to heavy distillate (HD), the highest-boiling material derived from the solvent refined coal-II (SRC-II) process, and the litters were examined at day 21. Adverse biological effects were observed in the group of animals exposed to an aerosol concentration of 0.66 mg 1-1 [1.8 microgram, mass medium aerodynamic diameter (MMAD)]; groups of animals exposed to lower aerosol concentrations (0.084 and 0.017 mg 1-1) were largely unaffected. Embryo lethality during mid- and late gestation appeared attributable to the coal liquid exposure. Fetuses from pregnant rats in the high exposure group were smaller in weight and length than fetuses from control animals, and skeletal ossification was reduced. Increased incidences of small lungs and cleft palate were observed in fetuses from the high exposure group. Pregnant rats in the high-exposure group gained less weight than controls during gestation; the reduced weight gain was accounted for by the reduced size of the fetuses and placentas. Even though maternal body weight (exclusive of the products of conception) was unaffected by the exposure, the weights of the maternal thymus, lung and spleen were altered in the high exposure group.
在妊娠第12至16天，将怀孕大鼠暴露于重馏分（HD）中，HD是溶剂精炼煤-II（SRC-II）工艺中沸点最高的物质，并在第21天检查产仔情况。在暴露于气溶胶浓度为0.66毫克/升[1.8微克，质量中值空气动力学直径（MMAD）]的动物组中观察到了不良生物学效应；暴露于较低气溶胶浓度（0.084和0.017毫克/升）的动物组基本未受影响。妊娠中期和后期的胚胎致死率似乎归因于煤液暴露。高暴露组怀孕大鼠所产胎儿的体重和长度均小于对照组动物所产胎儿，且骨骼骨化减少。在高暴露组胎儿中观察到小肺和腭裂的发生率增加。高暴露组怀孕大鼠在妊娠期间体重增加少于对照组；体重增加减少是由于胎儿和胎盘尺寸减小。尽管母体体重（不包括妊娠产物）不受暴露影响，但高暴露组母体胸腺、肺和脾脏的重量发生了改变。
