Hackett P L, Rommereim D N, Sikov M R
J Appl Toxicol. 1984 Feb;4(1):57-62. doi: 10.1002/jat.2550040111.
Heavy distillate (HD), the highest-boiling coal liquid from the solvent-refined coal-II process (SRC-II), was administered by intragastric (IG) intubation to pregnant rats. Five dose levels of HD (0.09, 0.14, 0.18, 0.36 and 0.74 g kg-1), were given daily from 12 to 16 days of gestation and the rats were killed at 20 days of gestation. Maternal body weights and weights of the liver, kidneys, spleen, adrenals, thymus, ovaries and the gravid uterus were obtained. Gravid uteri were evaluated for prenatal mortality. Live fetuses were examined for malformations and weighed; fetal lungs were excised and weighed. Maternal (extragestational) weight gains and thymic weights diminished in all groups that received the SRC material. Adrenal weights were increased in all treated animals, except for those in the lowest-dose group (0.9 g kg-1). There was significant maternal mortality at 0.74 g kg-1 and increased intrauterine mortality at doses of 0.37 and 0.74 g kg-1. Placental weight was depressed, and the incidence of fetal anomalies was increased at 0.14 g kg-1 and all higher dose levels.
重馏分油（HD）是溶剂精炼煤-II工艺（SRC-II）中沸点最高的煤液体，通过胃内（IG）插管法给予怀孕大鼠。在妊娠第12至16天每天给予五个剂量水平的HD（0.09、0.14、0.18、0.36和0.74 g kg-1），并在妊娠第20天处死大鼠。记录母体体重以及肝脏、肾脏、脾脏、肾上腺、胸腺、卵巢和妊娠子宫的重量。评估妊娠子宫的产前死亡率。检查存活胎儿的畸形情况并称重；切除胎儿肺部并称重。接受SRC材料的所有组中，母体（非妊娠期）体重增加和胸腺重量均减少。除最低剂量组（0.9 g kg-1）外，所有处理动物的肾上腺重量均增加。在剂量为0.74 g kg-1时出现显著的母体死亡率，在剂量为0.37和0.74 g kg-1时宫内死亡率增加。胎盘重量降低，在剂量为0.14 g kg-1及所有更高剂量水平时胎儿畸形发生率增加。
