Di Perri T, Laghi Pasini F, Capecchi P L, Orrico A, Pasqui A L
J Immunopharmacol. 1982;4(3):233-46. doi: 10.3109/08923978209026437.
In previous studies, we have demonstrated that levamisole was able to induce the activation of the alternate complement pathway as well as polysaccharide inductors inulin and zymosan. The knowledge that the activation of complement and the generation of C5a is followed "in vitro" and possibly "in vivo" by a rapid granulocyte aggregation suggested to study the levamisole-dependent changes of granulocyte aggregation "in vitro". Our findings showed that levamisole and inulin could induce granulocyte aggregation and granule-associated enzyme release through a specific triggering mechanism of complement activation. The possibility that a complement-induced granulocyte aggregation "in vivo" could operate in drug-dependent neutropenia was proposed.
在先前的研究中，我们已经证明左旋咪唑能够诱导替代补体途径以及多糖诱导剂菊粉和酵母聚糖的激活。补体激活和C5a的产生在“体外”以及可能在“体内”之后迅速发生粒细胞聚集，这一认识促使我们研究左旋咪唑在“体外”对粒细胞聚集的依赖性变化。我们的研究结果表明，左旋咪唑和菊粉可通过补体激活的特定触发机制诱导粒细胞聚集和颗粒相关酶释放。有人提出补体诱导的“体内”粒细胞聚集可能在药物依赖性中性粒细胞减少症中起作用。
