Ylikoski J, Collan Y, Palva T, Jauhiainen T
Arch Otolaryngol. 1978 Dec;104(12):679-84. doi: 10.1001/archotol.1978.00790120005001.
Correlative data between the histopathologic changes in the cochlear nerve and audiologic findings are reported in 16 cases of neurilemomas. Poor speech discrimination, positive or absent recruitment, excessive adaptation, or separation of forward vs reverse continuous tone Bekesy tracings did not correlate with the number of preserved nerve fibers. There were several cases with profound hearing loss in which the nerve fiber population approached normal. Histologically, pathologic changes included dilated fibers and increased interfibrillary collagen. In many specimens the fibers were further apart than normally, especially in the immediate vicinity of the tumor, and many lay between tumor cells. The tumor-nerve interface was usually gradual and no abrupt change appeared at the transition from the nerve to the tumor, the Schwann cells appearing to continue as tumor cells. Nonspecific changes apparently due to specimen handling were seen in some areas of most specimens.
报道了16例神经鞘瘤患者耳蜗神经组织病理学变化与听力学检查结果的相关数据。言语辨别力差、重振试验阳性或阴性、过度适应或正向与反向连续音Bekesy描记图分离与保留的神经纤维数量无关。有几例重度听力损失患者，其神经纤维数量接近正常。组织学上，病理变化包括纤维扩张和纤维间胶原增加。在许多标本中，纤维间距比正常情况更大，尤其是在肿瘤紧邻区域，许多纤维位于肿瘤细胞之间。肿瘤与神经的界面通常是渐变的，从神经到肿瘤的过渡处没有突然变化，施万细胞似乎延续为肿瘤细胞。在大多数标本的某些区域可见明显因标本处理导致的非特异性变化。
