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[乳糜泻、组织相容性抗原与免疫状态]

[Celiac disease, histocompatibility antigens and immunologic status].

作者信息

Boerr L A, Morales V H, Bai J C, Gándara M A, Barbatti A, Fink N, Morán C E, Higa R A

出版信息

Acta Gastroenterol Latinoam. 1982;12(4):333-49.

PMID:7185231
Abstract

Researched from immunologic and genetic point of view, 40 patients with Celiac Diseases confirmed and under-treatment. The results were compared with a group of 257 healthy people. The immunologic studies: leucocytes and lymphocytes in blood, the subpopulation of lymphocytes T and B, The immune-reaction studies of immunoglobulin Ig G, Ig M, Ig A and component C III complement didn't show difference between the comparative groups justified perhaps because the group of patients were under-treatment. In the antigen erythrocyte A B O and RHO (A), we can only in those assert that there is an increase of A and B group between the patients than who have O, and they were less exposed to get the disease. Between the histocompatibility antigen, the low presence of A9 B5 B7 BW16 antigen in Celiac patients could be a sign of protection against the disease, contrarily the presence of A1 B8 Dr3 Dr7 could indicate the high risk to get the disease. These finding confirm that the antigen group connected with the major System of histocompatibility, showed the susceptibility to suffer the disease.

摘要

从免疫学和遗传学角度对40例确诊并正在接受治疗的乳糜泻患者进行了研究。将结果与257名健康人群进行了比较。免疫学研究:血液中的白细胞和淋巴细胞、T和B淋巴细胞亚群、免疫球蛋白IgG、IgM、IgA以及补体CⅢ成分的免疫反应研究,在比较组之间未显示出差异,这可能是因为患者组正在接受治疗。在抗原红细胞ABO和RHO(A)方面,我们只能断言患者中A组和B组的人数比O组多,且他们患该病的几率较低。在组织相容性抗原方面,乳糜泻患者中A9、B5、B7、BW16抗原的低表达可能是预防该病的一个迹象,相反,A1、B8、Dr3、Dr7的存在可能表明患该病的高风险。这些发现证实,与主要组织相容性系统相关的抗原组显示出患该病的易感性。

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