Beuvery E C
J Infect. 1981 Mar;3(1 Suppl):71-9. doi: 10.1016/s0163-4453(81)80011-4.
The vaccine potential of different surface antigens of encapsulated bacteria is considered. It is concluded that only the capsular polysaccharides provide good protection. Polysaccharides are, however, thymus-independent antigens and the antibody response is strongly influenced by the age of the recipient and his naturally acquired immunity. For a long-lasting immunity the induction of mainly IgG antibodies is essential. Such a response can easily be induced by conjugates in which the polysaccharides have been attached to thymus-dependent carriers.
对有荚膜细菌不同表面抗原的疫苗潜力进行了研究。得出的结论是，只有荚膜多糖能提供良好的保护作用。然而，多糖是胸腺非依赖性抗原，抗体反应受到受者年龄及其自然获得的免疫力的强烈影响。为了获得持久免疫力，诱导主要产生IgG抗体至关重要。通过将多糖连接到胸腺依赖性载体上的结合物可以很容易地诱导出这种反应。
