Ayliffe T R, Noakes D E
Vet Rec. 1982 Jan 30;110(5):96-8. doi: 10.1136/vr.110.5.96.
The effects of oestradiol benzoate or of experimentally induced infection on the absorption of sodium benzylpenicillin from the uterus were investigated in three groups of clinically normal, non-pregnant, Friesian cows. All were at day 12 following the day of oestrus. Oestradiol benzoate in oil was administered either into the uterus or intramuscularly one hour before the infusion of 22,000 iu/kg of sodium benzylpenicillin. The dose of oestradiol benzoate was 10 mg, apart from one cow in each group which received 25 mg. Inflammation was induced by infusing a suspension of Corynebacterium pyogenes in Ringer's solution into the uterus, 11 to 18 hours before penicillin infusion. The degree of absorption of penicillin was greater in all three groups than that previously determined in cows given penicillin alone at the same stage of the cycle. The results indicate that factors which might affect blood flow to the uterus may also influence the absorption of sodium benzylpenicillin from the uterus.
在三组临床正常、未怀孕的弗里西亚奶牛中，研究了苯甲酸雌二醇或实验性诱导感染对子宫吸收苄青霉素钠的影响。所有奶牛均处于发情日后第12天。在输注22,000国际单位/千克苄青霉素钠前一小时，将油剂苯甲酸雌二醇注入子宫或肌肉注射。除每组有一头奶牛接受25毫克外，苯甲酸雌二醇的剂量为10毫克。在输注青霉素前11至18小时，通过向子宫内注入化脓棒状杆菌悬液于林格氏液中诱导炎症。三组中青霉素的吸收程度均高于先前在同一周期阶段单独给予青霉素的奶牛所测定的吸收程度。结果表明，可能影响子宫血流的因素也可能影响苄青霉素钠从子宫的吸收。
