Rybakowski J, Potok E, Strzyzewski W, Markowski S
Pol J Pharmacol Pharm. 1982 Nov-Dec;34(5-6):295-301.
Erythrocyte cation fluxes were measured in 30 patients with endogenous depression, before and after 14 days of treatment with antidepressant drugs, imipramine or nomifensine. Assays were made of active (ouabain-sensitive) transport of sodium and potassium as well as of lithium-sodium countertransport, reflecting sodium exchange diffusion. All the parameters studied increased significantly on 14th day of the thymoleptic treatment. The mean increase in activity of cation fluxes was similar in patients receiving imipramine or nomifensine. Patients with good clinical response to the treatment (as rated by the reduction of the initial intensity of depression on the Hamilton Scale on 21st day of therapy) had greater increase in ouabain-sensitive sodium flux than "non-responders". A possible role of cation transport processes in the mechanism of action of antidepressant drugs is discussed.
在30例内源性抑郁症患者中，在使用抗抑郁药物丙咪嗪或诺米芬辛治疗14天前后，测量了红细胞阳离子通量。对钠和钾的主动（哇巴因敏感）转运以及反映钠交换扩散的锂-钠逆向转运进行了测定。在抗抑郁治疗的第14天，所有研究参数均显著增加。接受丙咪嗪或诺米芬辛治疗的患者阳离子通量活性的平均增加相似。对治疗有良好临床反应的患者（根据治疗第21天汉密尔顿量表上抑郁初始强度的降低来评定），其哇巴因敏感的钠通量增加幅度大于“无反应者”。文中讨论了阳离子转运过程在抗抑郁药物作用机制中的可能作用。
