Kamei K, Tabata O, Muneoka K, Muraoka S I, Tomiyoshi R, Takigawa M
Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Japan.
Psychiatry Clin Neurosci. 1998 Oct;52(5):529-33. doi: 10.1046/j.1440-1819.1998.00426.x.
The concentrations of calcium, sodium, potassium and magnesium in the erythrocytes of patients were measured in the active and remission phases of depressive disorders. Twelve patients in the active phase and 19 patients in remission with major depression were studied and compared with 20 age-matched healthy controls. Patients with major depression in both active and remission phases showed significantly lower calcium concentrations in the erythrocytes compared with controls, although no significant differences in sodium, potassium or magnesium concentrations were found among the three groups. In addition, no differences were found in the electrolyte concentrations between the active and remission phases in the same patients. This calcium concentration had no relationship to the age, gender, or medication drugs of the subjects. Low calcium concentrations were found in the erythrocytes of depressed patients, which may be a relevant marker for depression.
在抑郁症的活动期和缓解期，对患者红细胞中的钙、钠、钾和镁浓度进行了测量。研究了12名处于活动期的患者和19名缓解期的重度抑郁症患者，并与20名年龄匹配的健康对照者进行比较。处于活动期和缓解期的重度抑郁症患者红细胞中的钙浓度均显著低于对照组，尽管三组之间钠、钾或镁浓度没有显著差异。此外，同一患者的活动期和缓解期之间电解质浓度没有差异。这种钙浓度与受试者的年龄、性别或药物无关。抑郁症患者的红细胞中发现低钙浓度，这可能是抑郁症的一个相关标志物。
