T4噬菌体中依赖标记的重组。I. 现象概述及表明错配修复机制的证据。
Marker-dependent recombination in T4 bacteriophage. I. Outline of the phenomenon and evidence suggesting a mismatch repair mechanism.
作者信息
Shcherbakov V P, Plugina L A, Kudryashova E A, Efremova O I, Sizova S T, Toompuu O G
出版信息
Genetics. 1982 Dec;102(4):615-25. doi: 10.1093/genetics/102.4.615.
Abstract
In standard crosses, some rIIB mutants of T4 phage were found to be susceptible to an extra recombination mechanism to which the other mutants were much less susceptible. The following observations were interpreted as evidence for the mismatch-repair nature of the phenomenon: (1) Marker-dependent recombination generates exclusively double exchanges at both sides of the marker. (2) Marker-dependent recombination is highly sensitive to DNA base sequence at the site of the marker and to that at the corresponding site on the chromosome of the other parent. (3) Within certain limits, the contribution of the marker-dependent mechanism to the total recombination frequency is distance-independent and thus constitutes a constant component.
摘要
在标准杂交实验中，发现T4噬菌体的一些rIIB突变体对一种额外的重组机制敏感，而其他突变体对该机制的敏感性则低得多。以下观察结果被解释为该现象错配修复性质的证据：（1）标记依赖型重组仅在标记两侧产生双交换。（2）标记依赖型重组对标记位点的DNA碱基序列以及另一亲本染色体上相应位点的序列高度敏感。（3）在一定限度内，标记依赖型机制对总重组频率的贡献与距离无关，因此构成一个恒定成分。
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