Murazian R I, Panchenkov N R
Antibiotiki. 1977 Sep;22(9):809-13.
The possibilities of antibacterial therapy in the clinics of burn diseases has at present decreased because of increasing microflora resistance to antibiotics. This phenomenon is one of the most often causes of antibacterial drug side effects in burn patients. For control of infections complications in burn patients which are most often lethal it is necessary to use biologically active subtance, such as prodigiozan and lysozime in addition to the directed antibiotic therapy. The use of specific antitoxic antistaphylococcal drugs, such as antistaphylococcal plasma and antistaphylococcal gamma-globulin in combination with the antibiotics of the direct action provided effective control of infectious complications and sepsis of staphylococcal genesis in burn patients. Decamine proved to be effective along with the usual use of nystatin in cases with dysbacteriosis as a result of the antibiotic side effects. In the patients treated with decamine the sings of candidosis disappeared by the 5th--7th day. Therefore, for decreasing the side effects of antibiotics in the clinics of burn patients it is expedient to use antibiotics in combination with the biologically active and immune preparations which increases the efficacy of antibiotic therapy, impfoves the treatment results and decreases the antibiotic side effects.
由于微生物对抗生素的耐药性增加，目前烧伤疾病临床中的抗菌治疗可能性降低。这种现象是烧伤患者抗菌药物副作用最常见的原因之一。为了控制烧伤患者最常导致死亡的感染并发症，除了针对性的抗生素治疗外，还必须使用生物活性物质，如灵菌红素和溶菌酶。使用特异性抗毒性抗葡萄球菌药物，如抗葡萄球菌血浆和抗葡萄球菌丙种球蛋白，与直接作用的抗生素联合使用，可有效控制烧伤患者葡萄球菌源性感染并发症和败血症。在因抗生素副作用导致菌群失调的病例中，除常规使用制霉菌素外，地卡明也被证明有效。在用过地卡明治疗的患者中，念珠菌病症状在第5至7天消失。因此，为了减少烧伤患者临床中抗生素的副作用，将抗生素与生物活性和免疫制剂联合使用是适宜的，这可提高抗生素治疗的疗效，改善治疗效果并减少抗生素副作用。
