Hartmann A
Ric Clin Lab. 1981;11 Suppl 1:243-6.
Twenty outpatients (8 women and 12 men; age range 52-66 years) with mild to moderate degree of cerebrovascular disorders and arteriosclerotic dementia, were randomly assigned to either control or pentoxifylline group (400 mg X 3/day/4 weeks p.o.). Measurements of cerebral blood flow (133Xe) show in the right hemisphere of the treated group a significant increase of fast perfused brain substance flow (Fg) in 7 out of the 10 cases and in the left hemisphere in 4 patients. In none of all treated subjects a significant reduction of mean Fg was observed. In the control group significant increase in 1 and significant reduction in another out of 20 hemispheres was observed. As for regional data, while significant elevation of Fg was observed in 36.7% of all recorded areas (114 out of 311) after pentoxifylline, this occurred only in 6.4% in the control group. The effect of pentoxifylline on cerebral perfusion in the different areas was independent of their location but was more pronounced in hypoperfused tissue.
二十名患有轻度至中度脑血管疾病和动脉硬化性痴呆的门诊患者（8名女性和12名男性；年龄范围52 - 66岁）被随机分配至对照组或己酮可可碱组（口服400毫克×3次/天，共4周）。脑血流测量（133Xe）显示，治疗组的10例患者中有7例右半球快速灌注脑实质血流（Fg）显著增加，4例患者左半球出现这种情况。在所有接受治疗的受试者中，均未观察到平均Fg显著降低。在对照组中，20个半球中有1个出现显著增加，另1个出现显著降低。至于区域数据，己酮可可碱治疗后，所有记录区域中有36.7%（311个区域中的114个）观察到Fg显著升高，而对照组仅为6.4%。己酮可可碱对不同区域脑灌注的影响与其位置无关，但在灌注不足的组织中更为明显。
