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皮肤松垂症绵羊成纤维细胞中前胶原转化率低，同时伴随着I型和III型胶原蛋白合成增加。

Low rate of procollagen conversion in dermatosparactic sheep fibroblasts is paralleled by increased synthesis of type I and type III collagens.

作者信息

Wiestner M, Rohde H, Helle O, Krieg T, Timpl R, Müller P K

出版信息

EMBO J. 1982;1(4):513-6. doi: 10.1002/j.1460-2075.1982.tb01200.x.

DOI:10.1002/j.1460-2075.1982.tb01200.x
PMID:7188350
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC553077/
Abstract

Dermatosparaxis is a genetic defect found in humans and animals, which affects the conversion of procollagen to collagen and aminopropeptides . Under cell culture conditions a reduction of the release of aminopropeptides is paralleled by an increased synthesis of collagens type I and III. This fact provides further evidence for a regulatory involvement of aminopropeptides in the biosynthesis of collagen.

摘要

皮肤松弛症是在人类和动物中发现的一种基因缺陷，它会影响前胶原向胶原蛋白和氨基端肽的转化。在细胞培养条件下，氨基端肽释放的减少与I型和III型胶原蛋白合成的增加同时出现。这一事实为氨基端肽参与胶原蛋白生物合成的调节提供了进一步的证据。

相似文献

1
Low rate of procollagen conversion in dermatosparactic sheep fibroblasts is paralleled by increased synthesis of type I and type III collagens.皮肤松垂症绵羊成纤维细胞中前胶原转化率低，同时伴随着I型和III型胶原蛋白合成增加。
EMBO J. 1982;1(4):513-6. doi: 10.1002/j.1460-2075.1982.tb01200.x.
2
Procollagen alpha 2(I) mRNA in dermatosparactic fibroblasts: evidence for post-transcriptional regulation.皮肤松解性成纤维细胞中的前胶原α2（I）mRNA：转录后调控的证据
EMBO J. 1983;2(8):1223-7. doi: 10.1002/j.1460-2075.1983.tb01573.x.
3
Immunohistologic analysis of fetal and dermatosparactic calf and sheep skin with antisera to procollagen and collagen type I.用抗前胶原和I型胶原抗血清对胎儿、皮肤松垂症小牛和绵羊皮肤进行免疫组织学分析。
Lab Invest. 1978 Aug;39(2):151-6.
4
Human dermatosparaxis: a form of Ehlers-Danlos syndrome that results from failure to remove the amino-terminal propeptide of type I procollagen.人类皮肤松弛症：一种埃勒斯-当洛综合征，由未能去除I型前胶原的氨基末端前肽所致。
Am J Hum Genet. 1992 Aug;51(2):235-44.
5
Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis.同源ADAMTS蛋白酶的特化对小鼠胚胎发育过程中前胶原氨基端前肽加工的调控：对胶原蛋白生物合成和皮肤松弛症的见解
Development. 2006 Apr;133(8):1587-96. doi: 10.1242/dev.02308.
6
Collagen biosynthesis by human skin fibroblasts. I. Optimization of the culture conditions for synthesis of type I and type III procollagens.人皮肤成纤维细胞的胶原蛋白生物合成。I. I型和III型前胶原合成培养条件的优化。
Biochim Biophys Acta. 1980 Mar 28;607(1):145-60. doi: 10.1016/0005-2787(80)90228-2.
7
Ultrastructural identification of extension aminopropeptides of type I and III collagens in human skin.人类皮肤中I型和III型胶原蛋白延伸氨基端肽的超微结构鉴定
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7360-4. doi: 10.1073/pnas.78.12.7360.
8
Modulation by recombinant interleukin 1 of synthesis of types I and III collagens and associated procollagen mRNA levels in cultured human cells.重组白细胞介素1对培养的人细胞中I型和III型胶原蛋白合成及相关前胶原mRNA水平的调节作用。
J Biol Chem. 1987 Dec 5;262(34):16724-9.
9
Collagen biosynthesis and type I and type III procollagen mRNA in lichen sclerosus et atrophicus.硬化萎缩性苔藓中的胶原蛋白生物合成及I型和III型前胶原mRNA
Arch Dermatol Res. 1990;282(7):480-3. doi: 10.1007/BF00402628.
10
Low production of procollagen III by skin fibroblasts from patients with Ehlers-Danlos syndrome type IV is not caused by decreased levels of procollagen III mRNA.患有IV型埃勒斯-当洛综合征患者的皮肤成纤维细胞中III型前胶原产量低并非由III型前胶原mRNA水平降低所致。
Eur J Clin Invest. 1988 Apr;18(2):207-12. doi: 10.1111/j.1365-2362.1988.tb02415.x.

引用本文的文献

1
Procollagen alpha 2(I) mRNA in dermatosparactic fibroblasts: evidence for post-transcriptional regulation.皮肤松解性成纤维细胞中的前胶原α2（I）mRNA：转录后调控的证据
EMBO J. 1983;2(8):1223-7. doi: 10.1002/j.1460-2075.1983.tb01573.x.
2
Processing of types I and III procollagen in Ehlers-Danlos syndrome type VII.Ⅶ型埃勒斯-当洛综合征中Ⅰ型和Ⅲ型前胶原的加工处理
Am J Hum Genet. 1986 Aug;39(2):222-31.
3
A defective cell surface collagen-binding protein in dermatosparactic sheep fibroblasts.皮肤松垂症绵羊成纤维细胞中存在缺陷的细胞表面胶原结合蛋白。
J Cell Biol. 1988 Jan;106(1):205-11. doi: 10.1083/jcb.106.1.205.
4
Feedback regulation of collagen gene expression: a Trojan horse approach.胶原蛋白基因表达的反馈调节：一种特洛伊木马策略。
Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10158-62. doi: 10.1073/pnas.88.22.10158.

本文引用的文献

1
KINETICS OF COLLAGEN SYNTHESIS BY ESTABLISHED MAMMALIAN CELL LINES.成熟哺乳动物细胞系中胶原蛋白合成的动力学
Nature. 1963 Dec 14;200:1097-8. doi: 10.1038/2001097a0.
2
Collagen types synthesized by isolated calvarium cells.由分离的颅骨细胞合成的胶原类型。
Exp Cell Res. 1981 May;133(1):115-25. doi: 10.1016/0014-4827(81)90362-1.
3
Ultrastructural identification of extension aminopropeptides of type I and III collagens in human skin.人类皮肤中I型和III型胶原蛋白延伸氨基端肽的超微结构鉴定
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7360-4. doi: 10.1073/pnas.78.12.7360.
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Some aspects of the modulation and regulation of collagen synthesis in vitro.体外胶原蛋白合成的调节与调控的某些方面。
Mol Cell Biochem. 1981 Jan 28;34(2):73-85. doi: 10.1007/BF02354861.
5
Regulation of protein synthesis: translational control by procollagen-derived fragments.蛋白质合成的调控：前胶原衍生片段的翻译控制
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6163-7. doi: 10.1073/pnas.78.10.6163.
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Assembly and processing of procollagen type III in chick embryo blood vessels.鸡胚血管中III型前胶原的组装与加工
J Biol Chem. 1981 Mar 10;256(5):2531-7.
7
Effects of procollagen peptides on the translation of type II collagen messenger ribonucleic acid and on collagen biosynthesis in chondrocytes.前胶原肽对软骨细胞中II型胶原信使核糖核酸翻译及胶原生物合成的影响。
Biochemistry. 1981 Jun 9;20(12):3523-7. doi: 10.1021/bi00515a034.
8
Phosphomannosyl-enzyme receptors in rat liver. Subcellular distribution and role in intracellular transport of lysosomal enzymes.大鼠肝脏中的磷酸甘露糖基酶受体。亚细胞分布及其在溶酶体酶细胞内运输中的作用。
J Biol Chem. 1980 Oct 25;255(20):9608-15.
9
Effect of cyclic AMP on the intracellular degradation of newly synthesized collagen.环磷酸腺苷对新合成胶原蛋白细胞内降解的影响。
J Biol Chem. 1980 Apr 10;255(7):2843-7.
10
The aminopropeptide of collagen.
Clin Orthop Relat Res. 1981 Jul-Aug(158):224-42.