Ziegler M G, Brooks B R, Lake C R, Wood J H, Enna S J
Neurology. 1980 Jan;30(1):98-101. doi: 10.1212/wnl.30.1.98.
Patients with amyotrophic lateral sclerosis have increased levels of the neutrotransmitter norepinephrine in blood and cerebrospinal fluid and depressed levels of the inhibitory neurotransmitter gamma-aminobutyric acid in cerebrospinal fluid. These neurochemical alterations are most marked in patients bedridden with advanced disease, appear interrelated, and lead to cardiovascular alterations in patients with amyotrophic lateral sclerosis.
肌萎缩侧索硬化症患者血液和脑脊液中的神经递质去甲肾上腺素水平升高，而脑脊液中抑制性神经递质γ-氨基丁酸水平降低。这些神经化学改变在晚期疾病卧床患者中最为明显，似乎相互关联，并导致肌萎缩侧索硬化症患者出现心血管改变。
