Krieger C, Perry T L, Ziltener H J
Department of Medicine, University of British Columbia, Vancouver, Canada.
Can J Neurol Sci. 1992 Aug;19(3):357-9.
Recent observations indicate that antibodies to gangliosides are found in many patients with amyotrophic lateral sclerosis (ALS). If antigen-antibody complexes occur in ALS, elevations of cytokine levels might be expected, among them the cytokine interleukin-6 (IL-6). IL-6 is secreted by activated monocytes and other cell types and is an important mediator of the inflammatory response. We have measured cerebrospinal fluid (CSF) IL-6 levels in patients with ALS and compared them with those in psychiatric and neurodegenerative disorders not believed to be due to immune disorders of the central nervous system. We found no significant differences in CSF IL-6 levels between these groups.
最近的观察表明，许多肌萎缩侧索硬化症（ALS）患者体内可检测到神经节苷脂抗体。如果ALS患者体内存在抗原-抗体复合物，那么细胞因子水平可能会升高，其中包括细胞因子白细胞介素-6（IL-6）。IL-6由活化的单核细胞和其他细胞类型分泌，是炎症反应的重要介质。我们检测了ALS患者脑脊液（CSF）中的IL-6水平，并将其与精神疾病和神经退行性疾病患者的水平进行比较，这些疾病被认为并非由中枢神经系统免疫紊乱所致。我们发现这些组之间的CSF IL-6水平没有显著差异。
