Susset J, Plante P
J Urol. 1980 Jan;123(1):70-4. doi: 10.1016/s0022-5347(17)55784-5.
Most pressure values, except U1 and areas under the curve, were significantly lower in the 456 curves obtained in 38 incontinent women than in normal subjects. Standard deviations of all parameters are important because of variations in the degree of patient relaxation, explaining a large overlapping zone in which curves from the incontinent and the normal groups are superimposed. There are 3 factors that cause a reduction in urethral pressure profile: 1) aging and menopause (which are attributed to reduction in urethral compliance), 2) multiparity and 3) previous significant urogynecological operations. Besides urethral compliance urethral pressure profile studies allow measurement of 5 other components of the urethral resistance: 1) the degree of patency of the vesical neck, 2) the maximum voluntary sphincter contraction, 3) the functional urethral length, 4) the facilitatory urethral relaxation reflex and 5) the degree of urethral displacement to some extent. Separate measurements of each urethral factor should allow a more accurate analysis of urethral resistance and, consequently, enhance the quality of therapeutic indications in the management of female incontinence.
在38名尿失禁女性所获得的456条曲线中，除U1和曲线下面积外，大多数压力值均显著低于正常受试者。由于患者放松程度的差异，所有参数的标准差都很重要，这解释了尿失禁组和正常组曲线叠加的一个大的重叠区域。导致尿道压力曲线降低的因素有3个：1）衰老和绝经（这归因于尿道顺应性降低），2）多产，3）既往重大的泌尿妇科手术。除了尿道顺应性，尿道压力曲线研究还可以测量尿道阻力的其他5个组成部分：1）膀胱颈通畅程度，2）最大自主括约肌收缩，3）功能性尿道长度，4）促进性尿道松弛反射，5）在一定程度上尿道移位程度。对每个尿道因素进行单独测量应能更准确地分析尿道阻力，从而提高女性尿失禁管理中治疗指征的质量。
