Johanson I B
Dev Psychobiol. 1980 Mar;13(2):111-21. doi: 10.1002/dev.420130203.
To determine whether maternal behavior could serve as a mediator for thyroid hormone effects on behavior, I assessed nesting, nursing, grooming, contact, and retrieval in mothers of hypothyroid, hyperthyroid, and control litters, as well as in mothers of litters receiving thyroxine replacement therapy. Females assigned to the hypothyroid and replacement therapy treatments were placed on a goitrogenic diet of .2% propylthiouracil from Day 15 of gestation to Day 22 postpartum. Hyperthyroid and replacement therapy pups were injected daily with thyroxine starting on the day of birth. The decline in nesting and nursing was delayed in hypothyroid litters whereas the decline in nesting was accelerated in hyperthyroid litters. Retrieval was not affected, but grooming of pups occurred less frequently in hypothyroid and replacement therapy litters. Maternal care received by hypothyroid pups was considered adequate. Maternal behavior may alleviate some of the effects of perinatal hypothyroidism,, but does not seem to be responsible for the more severe effects of hypothyroidism.
为了确定母体行为是否可作为甲状腺激素对行为影响的中介因素，我评估了甲状腺功能减退、甲状腺功能亢进和对照窝仔的母亲以及接受甲状腺素替代疗法窝仔的母亲的筑巢、哺乳、梳理、接触和找回行为。分配到甲状腺功能减退和替代疗法组的雌性从妊娠第15天到产后第22天食用含0.2%丙硫氧嘧啶的致甲状腺肿饮食。甲状腺功能亢进和替代疗法组的幼崽从出生当天开始每天注射甲状腺素。甲状腺功能减退窝仔的筑巢和哺乳行为下降延迟，而甲状腺功能亢进窝仔的筑巢行为下降加速。找回行为未受影响，但甲状腺功能减退和替代疗法窝仔对幼崽的梳理行为较少。甲状腺功能减退幼崽得到的母性照料被认为是足够的。母体行为可能会减轻围产期甲状腺功能减退的一些影响，但似乎并非甲状腺功能减退更严重影响的原因。
