Johanson I B, Turkewitz G, Hamburgh M
Dev Psychobiol. 1980 May;13(3):331-42. doi: 10.1002/dev.420130308.
In order to assess the effects of perinatal hypothyroidism or hyperthyroidism on the development of an integrated behavioral response, we tested hypothyroid, hyperthyroid, and control pups, as well as pups receiving thyroxine replacement therapy, for the development of the home orientation response. Hypothyroidism was induced in the pups by feeding the pregnant or lactating female a diet of .2% propylthiouracil from Day 15 of gestation to Day 22 postpartum. Pups receiving replacement therapy and pups made hyperthyroid were injected daily with thyroxine, starting at birth. The ability of the pups to initiate and maintain locomotion toward the nest was assessed between Days 4 and 22. Hyperthyroid, control, and replacement therapy pups behaved very similarly on the task, showing a peak in the percentage of pups homing between Days 12 and 16. Hypothyroid pups showed a delay in the peak percentage until Day 20, although the percentage of pups was similar to that found in other treatments. An integrated behavioral response can be delayed by hypothyroidism and still emerge apparently intact at a later age.
为了评估围产期甲状腺功能减退或甲状腺功能亢进对综合行为反应发育的影响，我们测试了甲状腺功能减退、甲状腺功能亢进和对照幼崽，以及接受甲状腺素替代疗法的幼崽的归巢定向反应的发育情况。从妊娠第15天到产后第22天，通过给怀孕或哺乳期的雌性喂食含0.2%丙硫氧嘧啶的饮食来诱导幼崽甲状腺功能减退。从出生开始，接受替代疗法的幼崽和甲状腺功能亢进的幼崽每天注射甲状腺素。在第4天至第22天之间评估幼崽启动并维持向巢穴移动的能力。甲状腺功能亢进、对照和替代疗法的幼崽在这项任务中的表现非常相似，在第12天至第16天之间归巢幼崽的百分比达到峰值。甲状腺功能减退的幼崽峰值百分比延迟到第20天，尽管幼崽的百分比与其他处理组相似。甲状腺功能减退会延迟综合行为反应，但在后期仍能明显完整地出现。
