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甲状腺功能减退和甲状腺功能亢进大鼠幼崽嗅觉和热反应性的发育

Development of olfactory and thermal responsiveness in hypothyroid and hyperthyroid rat pups.

作者信息

Johanson I B

出版信息

Dev Psychobiol. 1980 May;13(3):343-41. doi: 10.1002/dev.420130309.

DOI:10.1002/dev.420130309
PMID:7380106
Abstract

Hypo- and hyperthyroid rat pups were tested for their responsiveness on an olfactory and a thermal gradient in an attempt to evaluate the effects of perinatal thyroid manipulation on the ability of the pups to use these cues in orientation. Hypothyroid pups showed a delay and hyperthyroid pups an acceleration in the development of orientation along the olfactory gradient, relative to controls. None of the pups was able to utilize a thermal gradient in directed orientation but pups moved less at the warm end of the gradient than at the cool end. This differential responsiveness was strongest in the hypothyroid pups, suggesting that these pups could utilize thermal cues in an orthokinetic orientation.

摘要

对甲状腺功能减退和甲状腺功能亢进的幼鼠进行了嗅觉和热梯度反应测试,以评估围产期甲状腺操作对幼鼠利用这些线索进行定向能力的影响。相对于对照组,甲状腺功能减退的幼鼠在沿嗅觉梯度定向发育方面出现延迟,而甲状腺功能亢进的幼鼠则出现加速。没有一只幼鼠能够在定向运动中利用热梯度,但幼鼠在梯度的温暖端比在凉爽端移动得少。这种差异反应在甲状腺功能减退的幼鼠中最为明显,表明这些幼鼠可以在正动力学定向中利用热线索。

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1
Development of olfactory and thermal responsiveness in hypothyroid and hyperthyroid rat pups.甲状腺功能减退和甲状腺功能亢进大鼠幼崽嗅觉和热反应性的发育
Dev Psychobiol. 1980 May;13(3):343-41. doi: 10.1002/dev.420130309.
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Development of home orientation in hypothyroid and hyperthyroid rat pups.甲状腺功能减退和甲状腺功能亢进幼鼠的家定向能力发育
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Alterations in the maternal behavior of rats rearing hypothyroid and hyperthyroid offspring.饲养甲状腺功能减退和甲状腺功能亢进后代的大鼠的母性行为改变。
Dev Psychobiol. 1980 Mar;13(2):111-21. doi: 10.1002/dev.420130203.
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Modulation by thyroid hormones of the development of external plexiform layer in the rat olfactory bulb.甲状腺激素对大鼠嗅球外丛状层发育的调节作用。
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Lack of thyroid hormones but not their excess affects the maturation of olfactory receptor neurons: a quantitative morphologic study in the postnatal rat.甲状腺激素缺乏而非过量会影响嗅觉受体神经元的成熟:一项对新生大鼠的定量形态学研究。
Int J Dev Neurosci. 1991;9(5):439-52. doi: 10.1016/0736-5748(91)90030-p.
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The interrelationship between thermal and olfactory stimulation in the development of home orientation in newborn kittens.新生小猫归家定位发育过程中热刺激与嗅觉刺激之间的相互关系。
Dev Psychobiol. 1978 Sep;11(5):437-57. doi: 10.1002/dev.420110508.
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Changes in plasma homocysteine levels of rats with experimentally induced hypothyroidism and hyperthyroidism.实验性诱导甲状腺功能减退和甲状腺功能亢进大鼠血浆同型半胱氨酸水平的变化。
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NTP technical report on the toxicity studies of Dibutyl Phthalate (CAS No. 84-74-2) Administered in Feed to F344/N Rats and B6C3F1 Mice.美国国家毒理学计划关于邻苯二甲酸二丁酯(化学物质登记号84 - 74 - 2)经饲料给予F344/N大鼠和B6C3F1小鼠的毒性研究技术报告。
Toxic Rep Ser. 1995 Apr;30:1-G5.
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Changes in lipid peroxidation and free radical scavengers in kidney of hypothyroid and hyperthyroid rats.甲状腺功能减退和甲状腺功能亢进大鼠肾脏中脂质过氧化和自由基清除剂的变化。
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Behavioral modifications in relation to hypothyroidism and hyperthyroidism in adult rats.成年大鼠甲状腺功能减退和亢进相关的行为改变
Prog Neuropsychopharmacol Biol Psychiatry. 1989;13(6):927-40. doi: 10.1016/0278-5846(89)90044-4.

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