Rawat A K
Res Commun Chem Pathol Pharmacol. 1980 Jan;27(1):91-103.
The development of histaminergic pathways has been studied in the rat brain specially as influenced by maternal alcoholism. Maternal ethanol consumption during pregnancy results in an increase in the cerebral histamine levels of the fetus. An increase in the brain histamine levels is also observed in the newborn rats suckling on the ethanol-fed mothers compared to the corresponding controls. Brain histamine levels are highest towards latter part of the pregnancy and lowest in the adult brains, whereas the brain histidine decarboxylase activity is lowest in the fetal brains and highest in the adult brains. Maternal alcoholism either during gestation or during lactation did not significantly affect histidine decarboxylase activity in the fetal and neonatal brains. Acute administration of ethanol or acetaldehyde after 20 minutes resulted in significant increase in the brain histamine levels. This increase in the brain histamine levels seems to be a direct result of brain histamine release due to ethanol or acetaldehyde metabolism in the body. The effect of ethanol on brain histamine levels may have important implications inview of the fact that both histamine and ethanol influence diuresis, EEG activity, and thermoregulation in the body.
已经特别在大鼠大脑中研究了组胺能通路的发育，该发育受母体酒精中毒的影响。孕期母体摄入乙醇会导致胎儿大脑组胺水平升高。与相应对照组相比，吸食乙醇喂养的母亲乳汁的新生大鼠大脑组胺水平也会升高。大脑组胺水平在妊娠后期最高，在成年大脑中最低，而大脑组氨酸脱羧酶活性在胎儿大脑中最低，在成年大脑中最高。孕期或哺乳期的母体酒精中毒对胎儿和新生大脑中的组氨酸脱羧酶活性没有显著影响。20分钟后急性给予乙醇或乙醛会导致大脑组胺水平显著升高。大脑组胺水平的这种升高似乎是体内乙醇或乙醛代谢导致大脑组胺释放的直接结果。鉴于组胺和乙醇都会影响体内的利尿、脑电图活动和体温调节，乙醇对大脑组胺水平的影响可能具有重要意义。
