[Lipid peroxidation activation and the focal contracture injuries in the myocardium under emotional-pain stress].

Emotional-pain stress reproduced in the form of so called anxiety-neurosis provokes long-term activation of lipid peroxidation associated with an increased content of its products in the myocardium and the development of focal lesions of the contracture type in myocytes. These heart lesions are likely to be related to the impairment of active calcium release from myofibrils due to lipid hydroperoxides-induced injury to cell membranes responsible for the cation transport. While progressing the morphologic changes in the heart reach maximum, i. e. lead to complete contracture and necrosis of myocardial cells.