Juergens S M, Kurland L T, Okazaki H, Mulder D W
Neurology. 1980 May;30(5):463-70. doi: 10.1212/wnl.30.5.463.
The incidence, trend, and survivorship of ALS in the population of Rochester, Minnesota, was determined for the years 1925 through 1977. The average annual incidence was 1.76 per 100,000 population. There was a small but nonsignificant increase in the rate during the 53-year period. The male:female ratio was 1.1, and the male:female ratio of incidence rates was 1.6. The median age at onset was 66 years; the incidence rates increased with increasing age. Median survivorship was 22.5 months, and was longer for younger patients than for patients with an advanced age at onset. The demographic characteristics in this total community experience are believed to reflect the pattern of ALS more accurately than previously reported clinical series.
确定了1925年至1977年明尼苏达州罗切斯特市人群中肌萎缩侧索硬化症（ALS）的发病率、趋势和生存率。平均年发病率为每10万人1.76例。在这53年期间，发病率有小幅但不显著的上升。男女比例为1.1，发病率的男女比例为1.6。发病的中位年龄为66岁；发病率随年龄增长而增加。中位生存期为22.5个月，年轻患者的生存期比发病时年龄较大的患者更长。据信，这个整个社区人群的人口统计学特征比之前报道的临床系列更准确地反映了ALS的模式。
