Sandberg E C, Christian J C
Am J Obstet Gynecol. 1980 May 15;137(2):220-8. doi: 10.1016/0002-9378(80)90778-4.
Monozygotic, 17-year-old, female twins exposed to diethylstilbestrol (DES) in utero and discordant for cervicovaginal clear cell adenocarcinoma are reported. Benign teratologic changes were present in both. The twin with cancer was treated by extensive operation and postoperative irradiation. No tumor has appeared in either twin in the 4 years subsequent to therapy. Discordance for cervicovaginal clear cell adenocarcinoma in this situation suggests that factors other than embryonic exposure to DES, extrauterine in location and nongenetic in character, were operative in tumorigenesis. The twins were compared in regard to lifetime radiation exposure and evidence of previous viral disease. The only substantial difference was an elevated titer of antibody in the twin with cancer to the capsid antigen of the Epstein-Barr virus, a herpesvirus with oncogenic capability.
据报道，有一对单卵双生的17岁女性双胞胎，在子宫内接触过己烯雌酚（DES），其中一人患有宫颈阴道透明细胞腺癌，另一人未患此病。两人均有良性致畸性改变。患癌的双胞胎接受了广泛手术及术后放疗。治疗后的4年里，两姐妹均未再出现肿瘤。在这种情况下，宫颈阴道透明细胞腺癌的不一致性表明，除了胚胎期接触DES外，其他位于子宫外且非遗传性质的因素在肿瘤发生过程中也起了作用。对这对双胞胎在终生辐射暴露情况及既往病毒感染证据方面进行了比较。唯一显著的差异是患癌双胞胎体内针对爱泼斯坦 - 巴尔病毒（一种具有致癌能力的疱疹病毒）衣壳抗原的抗体滴度升高。
