Osborne B, Seggie J
J Comp Physiol Psychol. 1980 Jun;94(3):536-46. doi: 10.1037/h0077688.
These experiments examined the behavioral, corticosterone, and prolactin responses to a novel environmental in male rats with total fornix transections. During the initial exposure to the novel environment, rats with fornix transections exhibited increased latency to initiate activity and increased activity levels. There were no changes in frequency of rearing, frequency of interactions with objects in the environment, or defecation. Fornix transection was found to have no effect on resting levels of either corticosterone or prolactin but to alter significantly the stress-response profiles of each of these hormones. The corticosterone responses to the novel environment in rats with fornix lesions were of greater magnitude with no change in latency to respond or in recovery of resting levels, whereas the prolactin responses were of shorter latency with no change in magnitude or recovery or resting levels. Habituating to the novel environment by repeated exposure was found to decrease the corticosterone responses of rats with fornix lesions but not the responses of controls. The results are discussed in terms of differences between rats with fornix lesions and control rats in level of arousal and effect of experience in the environment.
这些实验研究了完全穹窿横断的雄性大鼠对新环境的行为、皮质酮和催乳素反应。在初次暴露于新环境期间，穹窿横断的大鼠开始活动的潜伏期延长，活动水平增加。竖毛频率、与环境中物体的互动频率或排便情况均无变化。发现穹窿横断对皮质酮或催乳素的静息水平没有影响，但会显著改变这两种激素的应激反应模式。穹窿损伤大鼠对新环境的皮质酮反应幅度更大，反应潜伏期和静息水平恢复时间均无变化，而催乳素反应潜伏期较短，幅度、恢复或静息水平均无变化。通过反复暴露使大鼠适应新环境，发现这会降低穹窿损伤大鼠的皮质酮反应，但不会降低对照组大鼠的反应。根据穹窿损伤大鼠和对照大鼠在觉醒水平和环境经验影响方面的差异对结果进行了讨论。
