Delaney T J, Rowlingson J C, Carron H, Butler A
Anesth Analg. 1980 Aug;59(8):610-4.
There have been encouraging reports of symptomatic improvement in patients with low back pain following injection of a mixture of a local anesthetic and a corticosteroid into the lumbar epidural space. However, there is a lack of animal or human studies which examined possible long-term effects of this combination on the exposed neural tissues. This study evaluated by both light and electron microscopy the effect of triamcinolone diacetate in vehicle and of the vehicle itself (both in 2% lidocaine) in 48 cats after percutaneous epidural injections were done at the lumbosacral space. When the animals were killed at 30 or 120 days, specimens of the spinal root, the root exit zone, and the meninges at the level of injection and level above and below were obtained. Because all of the histologic findings were found to be mild, it is concluded that local anesthetic-steroid combinations do not cause significant damage to neural tissues.
有令人鼓舞的报告称，将局部麻醉剂和皮质类固醇的混合物注入腰椎硬膜外腔后，腰痛患者的症状有所改善。然而，缺乏动物或人体研究来检验这种组合对暴露的神经组织可能产生的长期影响。本研究通过光学显微镜和电子显微镜评估了在48只猫经皮腰荐部硬膜外注射后，醋酸曲安奈德于溶媒中以及溶媒本身（均在2%利多卡因中）的作用。当动物在30天或120天时被处死，获取注射部位及其上下水平的脊神经根、神经根出口区和脑膜的标本。由于所有组织学发现均为轻度，得出的结论是局部麻醉剂 - 类固醇组合不会对神经组织造成显著损伤。
