Sutton J R
J Appl Physiol Respir Environ Exerc Physiol. 1977 Apr;42(4):587-92. doi: 10.1152/jappl.1977.42.4.587.
The hormonal responses to submaximal exercise under normoxic and hypoxic conditions were studied in eight fit males, aged 22--28 yr, with mean maximal oxygen uptake of 4.4 +/- 0.7 l/min. Studies were performed in a hypobaric chamber, decompressed to a simulated altitude of 4,550 m (PIO2 = 83 Torr). The subjects exercised for 20 min at 750 kpm/min on a cycle ergometer. Venous blood samples were obtained at rest, during exercise and for 60 min after exercise. Plasma glucose, free fatty acids, lactate, cortisol, and serum growth hormone concentrations all increased more during hypoxic exercise than under normoxic conditions. Serum insulin concentration showed a small decrease under normoxic conditions, but decreased by 50% during hypoxic exercise, and was followed by marked rebound when exercise stopped. These changes suggest that energy substrate-hormone interrelationships are altered by hypoxic exercise, resulting in increased fat mobilization and increased gluconeogenesis.
对8名年龄在22至28岁之间、平均最大摄氧量为4.4±0.7升/分钟的健康男性，研究了常氧和低氧条件下对次最大运动的激素反应。研究在低压舱内进行，减压至模拟海拔4550米（PIO2 = 83托）。受试者在自行车测力计上以750千帕米/分钟的速度运动20分钟。在休息时、运动期间和运动后60分钟采集静脉血样本。与常氧条件相比，低氧运动期间血浆葡萄糖、游离脂肪酸、乳酸、皮质醇和血清生长激素浓度的升高幅度都更大。血清胰岛素浓度在常氧条件下略有下降，但在低氧运动期间下降了50%，运动停止后随之出现明显反弹。这些变化表明，低氧运动改变了能量底物与激素之间的相互关系，导致脂肪动员增加和糖异生增加。
