Sakamoto S, Yasuda H, Honma H, Kudo T, Mikami T
Hokkaido Igaku Zasshi. 1980 Jan;55(1):15-22.
Multistage treadmill stress testing was performed in 24 patients with idiopathic cardiomyopathy using Bruce protocol. 5 patients were considered to have hypertrophic obstructive cardiomyopathy (HOCM), 12 hypertrophic nonobstructive cardiomyopathy (HCM) and 7 congestive cardiomyopathy (CCM). Heart rate, systemic blood pressure, electrocardiographic changes and exercise tolerance were observed. The effect of propranolol on exercise tolerance was investigated in HOCM and HCM. 1) Exercise duration was less in patients with HCM and HOCM than in normal subjects (50 subjects) and greater than in 50 anginal patients. In CCM, exercise duration was the least. 2) Electrocardiographic changes observed in HCM and HOCM were increase of T waves and lessening of ST depression. In CCM, appearance of ventricular arrhythmia was noted in 4 of 7 patients. 3) Maximam exercise tolerance was reached at Bruce state III-IV in HOCM, stage III in HCM and stage II in CCM. 4) Propranolol administration resulted in improvement of exercise tolerance in 3 of 7 patients with HOCM and HCM.
对24例特发性心肌病患者采用布鲁斯方案进行多级平板运动试验。5例被诊断为肥厚性梗阻性心肌病（HOCM），12例为肥厚性非梗阻性心肌病（HCM），7例为充血性心肌病（CCM）。观察心率、体循环血压、心电图变化及运动耐量。研究了普萘洛尔对HOCM和HCM患者运动耐量的影响。1）HCM和HOCM患者的运动持续时间比正常受试者（50例）短，但比50例心绞痛患者长。在CCM患者中，运动持续时间最短。2）HCM和HOCM患者观察到的心电图变化为T波增高和ST段压低减轻。在CCM患者中，7例中有4例出现室性心律失常。3）HOCM患者在布鲁斯方案III-IV级达到最大运动耐量，HCM患者在III级，CCM患者在II级。4）7例HOCM和HCM患者中，3例在服用普萘洛尔后运动耐量得到改善。
