Fishman J, Martucci C
J Clin Endocrinol Metab. 1980 Sep;51(3):611-5. doi: 10.1210/jcem-51-3-611.
Metabolism of estradiol in men with cirrhosis and subjects with systemic lupus erythematosus results in an excessive formation of 16 alpha-hydroxyestrone. Examination of the biological activity of this metabolite showed that it is a potent uterotropic agent and that it exhibits minimal affinity for the human sex hormone-binding globulin. These biological characteristics are consistent with a hyperestrongenic response to the substance, which may be reflected in the pathology and etiology of these diseases.
肝硬化男性和系统性红斑狼疮患者体内雌二醇的代谢会导致16α-羟基雌酮过度生成。对这种代谢物的生物活性检测表明，它是一种强效的子宫促生长剂，并且对人类性激素结合球蛋白的亲和力极低。这些生物学特性与对该物质的雌激素过多反应相一致，这可能在这些疾病的病理和病因中有所体现。
