Gilbert D A
Biosystems. 1978 Aug;10(3):227-33. doi: 10.1016/0303-2647(78)90003-5.
The oscillator concept of the cell cycle suggests that regulation of replication is achieved through a switch-like process. This is triggered when the values of parameters governing the behaviour of an intracellular control system exceed thresholds (bifurcations) which separate oscillatory and non-oscillatory (or damped oscillatory) modes of operation. On this basis it becomes possible to explain (a) how a given regulator can have diverse effects, (b) how distinct agents can have similar responses and (c) how various agents interact when controlling replication. The relevance of the malignant transformation is also briefly discussed.
细胞周期的振荡器概念表明，复制的调控是通过类似开关的过程实现的。当控制细胞内控制系统行为的参数值超过将振荡模式与非振荡（或阻尼振荡）操作模式区分开的阈值（分歧点）时，就会触发这种调控。在此基础上，就有可能解释：（a）给定的调节因子如何能产生多种效应；（b）不同的因子如何能有相似的反应；以及（c）各种因子在控制复制时是如何相互作用的。还简要讨论了恶性转化的相关性。
