Gilbert D A
Biosystems. 1978 Aug;10(3):235-40. doi: 10.1016/0303-2647(78)90004-7.
The oscillator concept of the cell cycle predicts the existence of threshold conditions within the cell which must be exceeded before replication is initiated. It is shown (a) that if the conditions are subthreshold, random disturbances can trigger a cycle of the oscillation (round of replication) and (b) that the probability of this occurring increases as the state of the system approaches the threshold. It is concluded that the oscillator concept explains the data on which the transition probability model is based. It also accounts for the ability of cells to replicate even when the mitogen is present for a limited period only.
细胞周期的振荡器概念预测细胞内存在阈值条件，在复制开始之前必须超过该阈值。结果表明：（a）如果条件低于阈值，随机干扰可触发振荡周期（一轮复制）；（b）随着系统状态接近阈值，这种情况发生的概率会增加。得出的结论是，振荡器概念解释了转变概率模型所基于的数据。它还解释了即使有丝分裂原仅存在有限时间，细胞仍能进行复制的能力。
