Wisser H, Knoll E, Schmid G
J Clin Chem Clin Biochem. 1980 May;18(5):297-301.
The diurnal rhythm of total acid phosphatase and prostatic phosphatase activities was investigated in patients with prostate carcinoma. In these patients, the activities of total acid phosphatase, the tartrate-sensitive fraction of acid phosphatase, and lactate dehydrogenase decrease after therapy, whereas the activity of alkaline phosphatase increases. In all patients with prostate carcinoma, the total and tartrate-inhibited acid phosphatase, and the level of cortisol show a diurnal rhythm before therapy, with a minimum at night. In one patient, after orchiectomy, the cortisol rhythm remained unchanged, but the daily phosphatase variation was absent. Diurnal variations of lactate dehydrogenase and alkaline phosphatase were also observed in 2 patients without prostate carcinoma, but with elevated levels of these enzymes.
对前列腺癌患者的总酸性磷酸酶和前列腺磷酸酶活性的昼夜节律进行了研究。在这些患者中，治疗后总酸性磷酸酶、酸性磷酸酶的酒石酸敏感部分以及乳酸脱氢酶的活性降低，而碱性磷酸酶的活性增加。在所有前列腺癌患者中，治疗前总酸性磷酸酶和酒石酸抑制的酸性磷酸酶以及皮质醇水平呈现昼夜节律，夜间最低。在一名患者中，睾丸切除术后，皮质醇节律保持不变，但磷酸酶的每日变化消失。在2名无前列腺癌但这些酶水平升高的患者中也观察到了乳酸脱氢酶和碱性磷酸酶的昼夜变化。
