人前列腺酸性磷酸酶和前列腺特异性抗原基因在肿瘤组织和良性组织中的表达。
Expression of human prostatic acid phosphatase and prostate specific antigen genes in neoplastic and benign tissues.
作者信息
Sharief F S, Mohler J L, Sharief Y, Li S S
机构信息
Laboratory of Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709.
出版信息
Biochem Mol Biol Int. 1994 Jun;33(3):567-74.
Expression of human prostatic acid phosphatase (ACPP) and prostate specific antigen (PSA) genes in prostatic carcinoma (CAP) and benign prostatic hyperplasia (BPH) was investigated by northern blot analyses. The expressions of ACPP and PSA, as well as the glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and lactate dehydrogenase-muscle (LDH-A), were elevated significantly in prostatic carcinoma when compared with the expressions of these genes in benign prostatic hyperplasia in the same patient. The expression of the actin gene in both neoplastic and benign hyperplasia remained the same.
通过Northern印迹分析研究了人前列腺酸性磷酸酶（ACPP）和前列腺特异性抗原（PSA）基因在前列腺癌（CAP）和良性前列腺增生（BPH）中的表达。与同一患者良性前列腺增生中这些基因的表达相比，前列腺癌中ACPP和PSA以及糖酵解酶甘油醛-3-磷酸脱氢酶（GAPDH）和肌肉乳酸脱氢酶（LDH-A）的表达显著升高。肌动蛋白基因在肿瘤性增生和良性增生中的表达保持不变。
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