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[舒必利治疗的精神分裂症患者视觉诱发电位的研究]

[Study of visually evoked potentials in schizophrenic patients treated with sulpiride].

作者信息

Brosteanu E R, Floru L

出版信息

Arzneimittelforschung. 1980;30(8):1306-9.

PMID:7192148
Abstract

A review on the clinical properties of sulpiride (Dogmatil forte) which up to the present day are yet accepted unanimously is presented. By means of visually evoked potentials (VEP) a study was carried out in 25 schizophrenic patients during an observation period of 24 days. The analysis of amplitudes and latencies of VEPs with dosages from 200 mg/day up to 1200 mg/day showed that low doses (200 mg/day) have a thymoleptic VEP profile, similar to that of amitriptyline, whereas dosages of 600--1200 mg/day show a medium to strong neuroleptic action, similar in its VEP profile to those of perphenazine and fluphenazine.

摘要

本文对至今仍被一致认可的舒必利(大剂量舒必利)的临床特性进行了综述。通过视觉诱发电位(VEP),对25例精神分裂症患者进行了为期24天的观察期研究。对剂量从200毫克/天至1200毫克/天的VEP振幅和潜伏期分析表明,低剂量(200毫克/天)具有抗抑郁的VEP特征,类似于阿米替林,而600 - 1200毫克/天的剂量表现出中度至强的抗精神病作用,其VEP特征类似于奋乃静和氟奋乃静。

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