Brosteanu E R, Floru L
Arzneimittelforschung. 1977;27(6):1231-3.
The paper describes a study of visually evoked potentials (VEP) during 50 days in a schizophrenic female patient to whom we administered increasing dosages (from 150 mg up to 600 mg) and afterwards progressively decreasing ones (from 600 mg to 20 mg) of 10-(3-[4-(2-hydroxyethyl)-1-piperazinyl]-propyl)-2-trifluoromethylphenothiazine (fluphenazine-dihydrochloride). We tried to establish a relation between the aspect of latencies and form of curves and the dosages. We also discussed a possible correspondence between VEP and psychopathological changes.
本文描述了对一名精神分裂症女性患者进行的为期50天的视觉诱发电位(VEP)研究。我们给该患者服用了剂量递增(从150毫克增至600毫克)然后逐渐递减(从600毫克减至20毫克)的10-(3-[4-(2-羟乙基)-1-哌嗪基]-丙基)-2-三氟甲基吩噻嗪(盐酸氟奋乃静)。我们试图确定潜伏期和曲线形态与剂量之间的关系。我们还讨论了VEP与精神病理变化之间可能存在的对应关系。