L-色氨酸和单胺氧化酶抑制剂对大鼠脑内儿茶酚胺代谢的影响。
The influence of L-tryptophan and monoamine oxidase inhibitors on catecholamine metabolism in rat brain.
作者信息
Eccleston D, Nicolaou N
出版信息
Br J Pharmacol. 1978 Nov;64(3):341-5. doi: 10.1111/j.1476-5381.1978.tb08655.x.
Abstract
- L-Tryptophan (100 mg/kg) was administered to rats with or without pretreatment with a monoamine oxidase inhibitor and the concentration of 5-hydroxyindoleacetic acid, homovanillic acid, dihydroxyphenylacetic acid, 3-methoxy 4-hydroxyphenyl glycol, normetanephrine, noradrenaline and dopamine measured in whole brain one hour later. 2. L-Tryptophan increased the concentration of 5-hydroxyindoleacetic acid, homovanillic acid, dihydroxyphenylacetic acid, 3-methoxy 4-hydroxyphenyl glycol and normetanephrine. The concentration of noradrenaline did not change whilst that of dopamine increased significantly. 3. In animals pretreated chronically with a monoamine oxidase inhibitor, tryptophan increased the concentration of dihydroxyphenylacetic acid and homovanillic acid compared to monoamine oxidase alone. 4. The results suggest either a release of dopamine and noradrenaline by 5-hydroxytryptamine, with a compensatory increase in their synthesis, or an increase in the firing of dopaminergic and noradrenergic neurones after L-tryptophan.
摘要
- 给大鼠注射L-色氨酸（100毫克/千克），无论其是否预先用单胺氧化酶抑制剂处理，1小时后测定全脑中5-羟吲哚乙酸、高香草酸、二羟基苯乙酸、3-甲氧基4-羟基苯乙二醇、去甲变肾上腺素、去甲肾上腺素和多巴胺的浓度。2. L-色氨酸增加了5-羟吲哚乙酸、高香草酸、二羟基苯乙酸、3-甲氧基4-羟基苯乙二醇和去甲变肾上腺素的浓度。去甲肾上腺素浓度未变，而多巴胺浓度显著增加。3. 在长期用单胺氧化酶抑制剂预处理的动物中，与单用单胺氧化酶抑制剂相比，色氨酸增加了二羟基苯乙酸和高香草酸的浓度。4. 结果表明，要么是5-羟色胺释放多巴胺和去甲肾上腺素，并使其合成代偿性增加，要么是L-色氨酸后多巴胺能和去甲肾上腺素能神经元的放电增加。
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A fluorometric procedure for the measurement of tryptamine in tissues.一种用于测量组织中色胺的荧光测定法。
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