Drozhennikov V A, Guberni M A, Orlova E B, Perevezentseva O S
Biokhimiia. 1977 Aug;42(8):1432-8.
Immune gamma-globulins containing antibodies to bovine DNAse I inhibit activities of bovine and mouse DNAse I both in vitro and in vivo. Bovine DNAse I was used as exogenous DNAse I in the in vivo studies and was injected to mice intraperitoneally in combination with gamma-globulins. The serous fluid of mice was used as a source of endogenous DNAse I. Both in in vitro and in vivo studies immune gamma-globulins caused a practically complete inhibition of bovine DNAse I activity, whereas the activity of mouse DNAse I (endogenous) was inhibited by 60-80%. Nonimmune gamma-globulins had no inhibitory effects whatsoever.
含有抗牛脱氧核糖核酸酶I抗体的免疫γ球蛋白在体外和体内均能抑制牛和小鼠脱氧核糖核酸酶I的活性。在体内研究中，牛脱氧核糖核酸酶I被用作外源性脱氧核糖核酸酶I，并与γ球蛋白一起腹腔注射到小鼠体内。小鼠的浆液用作内源性脱氧核糖核酸酶I的来源。在体外和体内研究中，免疫γ球蛋白均能几乎完全抑制牛脱氧核糖核酸酶I的活性，而小鼠脱氧核糖核酸酶I（内源性）的活性则被抑制60-80%。非免疫γ球蛋白没有任何抑制作用。
