长期乙醇摄入对大鼠肝脏中芳香烃和氯代烃代谢的影响。
Effects of chronic ethanol consumption on hepatic metabolism of aromatic and chlorinated hydrocarbons in rats.
作者信息
Sato A, Nakajima T, Koyama Y
出版信息
Br J Ind Med. 1980 Nov;37(4):382-6. doi: 10.1136/oem.37.4.382.
Abstract
The activities of liver drug-metabolising enzymes for 16 aromatic or chlorinated hydrocarbons were measured in male rats after a three-week daily intake of ethanol amounting to 30% of total energy intake. Although the ethanol feeding produced only a slight increase in the microsomal cytochrome P-450 content, it increased the in-vitro metabolism of most hydrocarbons three-to six-fold. That a major part of this enhanced activity disappeared after one-day withdrawal of ethanol suggests that recent intake of ethanol plays an important part in accelerating the metabolism of hydrocarbons. The enzyme activity enhanced by ethanol was found to be related with changes occurring not in the soluble but in the microsomal fractions. A metabolism study using toluene as a model substrate indicated that chronic ethanol consumption increases the in-vivo metabolism of this hydrocarbon in rats.
摘要
在雄性大鼠中，每日摄入占总能量摄入30%的乙醇，持续三周后，测定了16种芳香烃或氯代烃的肝脏药物代谢酶活性。尽管喂食乙醇仅使微粒体细胞色素P - 450含量略有增加，但它使大多数烃类的体外代谢增加了三至六倍。乙醇摄入一天后，这种增强的活性大部分消失，这表明近期摄入乙醇在加速烃类代谢中起重要作用。发现乙醇增强的酶活性与微粒体部分而非可溶性部分发生的变化有关。一项以甲苯为模型底物的代谢研究表明，长期摄入乙醇会增加大鼠体内这种烃类的代谢。
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